EVERY TUBE OF TOOTHPASTE with the ADA's Seal of Acceptance has the same two things in common: it is sugar-free and it contains fluoride. Fluoride is a key building block in our tooth enamel. The sugary or acidic things we eat and drink pull minerals out of our enamel, and we can build it back up by brushing with fluoride toothpaste. This is also why trace amounts of fluoride are added to our drinking water.